More bad weather in the early afternoon led to the 250cc race being abandoned and the early part of the MotoGP race was run on a very wet track. Rossi dropped to fourth at the start and then surrendered another place to Lorenzo on the next lap, but he soon found his rhythm and made his way back past Casey Stoner, Lorenzo and Andrea Dovizioso into second behind Nicky Hayden by lap six. Passing Hayden was no mean feat and it took the seven-time world champion another eight laps to finally get by the American, at which point he quickly began to pull away. Hurricane Ike was not finished with Indianapolis however and on lap 16 of 28 it started to rain heavily once again, accompanied by strong gusts of wind which became very dangerous. The race was eventually red-flagged after 20 laps and, after a few minutes confusion as to whether there would be a restart, Rossi was confirmed as the first ever MotoGP winner at the Brickyard.

Rossi`s 69th win takes him ahead of his fellow countryman Giacomo Agostini to the top of the all-time premier class winners list, a record which has stood for more than 30 years. Agostini claimed the 1975 500cc title with Yamaha and won six of his 68 victories with the Japanese factory.

Rossi is now 87 points clear of Stoner, who finished fourth today, which means he is able to win the championship at the next round in Motegi by finishing fourth or above.